Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977573 | 1.00 | MAPT (0.37) | MAPTKMT2AMEN1TRPV1CASP3 | |
| SCHEMBL7568322 | 0.81 | HTR7 (0.45) | MAPTKMT2AMEN1TRPV1CASP3 | |
| SCHEMBL7568325 | 0.81 | HTR7 (0.45) | MAPTKMT2AMEN1TRPV1CASP3 | |
| SCHEMBL7565431 | 0.78 | MAPT (0.47) | MAPTKMT2AMEN1TRPV1CASP3 | |
| SCHEMBL7565428 | 0.78 | MAPT (0.47) | MAPTKMT2AMEN1TRPV1CASP3 | |
| SCHEMBL9977570 | 0.77 | HTR7 (0.33) | LMNAHTR7 | |
| SCHEMBL11907845 | 0.77 | KMT2A (0.38) | MAPTKMT2AMEN1TRPV1CASP3 | |
| SCHEMBL11920542 | 0.77 | KMT2A (0.38) | MAPTKMT2AMEN1TRPV1CASP3 | |
| SCHEMBL11920540 | 0.77 | KMT2A (0.38) | MAPTKMT2AMEN1TRPV1CASP3 | |
| SCHEMBL9977595 | 0.76 | ADRB2 (0.36) | KMT2AMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2465847-B1 | AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF | ZHEJIANG HISUN PHARM CO LTD (CN) | 2016-10-12 | — | — | EP | disclosed |
| US-8623855-B2 | Azetidinone compounds and medical use thereof | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2014-01-07 | — | — | US | disclosed |