Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of Hymecromone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.84 |
| ▸ | CA9 | Q16790 | 7/20 | 0.84 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.84 |
| ▸ | CA12 | O43570 | 5/20 | 0.84 |
| ▸ | HPGD | P15428 | 4/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.84 |
| ▸ | GAA | P10253 | 4/20 | 0.84 |
| ▸ | GLA | P06280 | 3/20 | 0.84 |
| ▸ | CASP1 | P29466 | 2/20 | 0.84 |
| ▸ | CASP7 | P55210 | 2/20 | 0.84 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.84 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.84 |
| ▸ | LMNA | P02545 | 1/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.84 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.84 |
| ▸ | KDR | P35968 | 1/20 | 0.84 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hymecromone SCHEMBL720434 | 0.98 | KDM4E (0.87) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL10850194 | 0.94 | ALDH1A1 (0.84) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL29364837 | 0.92 | HSD17B3 (1.00) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL24150 | 0.92 | HSD17B3 (1.00) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL2357040 | 0.92 | HSD17B3 (1.00) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL29624431 | 0.92 | HSD17B3 (1.00) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL31014 | 0.90 | HSD17B3 (0.96) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL27924142 | 0.90 | HSD17B3 (0.96) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL15418603 | 0.89 | KDM4E (0.82) | KDM4EALDH1A1CA9HSD17B3CA12 | |
| Hymecromone SCHEMBL27728511 | 0.89 | HSD17B3 (0.93) | KDM4EALDH1A1CA9HSD17B3CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190040446-A1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | GODO SHUSEI CO., LTD. (JP) | 2019-02-07 | — | — | US | claimed |
| EP-2687598-B1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | GODO SHUSEI KK (JP) | 2017-02-15 | — | — | EP | claimed |
| US-20170029865-A1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | GODO SHUSEI CO., LTD. (JP) | 2017-02-02 | — | — | US | claimed |
| US-20140087404-A1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | GODO SHUSEI CO., LTD. (JP) | 2014-03-27 | — | — | US | claimed |
| EP-2687598-A1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | Godo Shusei Co., Ltd. (JP) | 2014-01-22 | — | — | EP | claimed |
| CN-116063525-A | Novel anti-human transferrin receptor antibodies across the blood brain barrier | JCR制药股份有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-109983031-B | Novel anti-human transferrin receptor antibodies across the blood brain barrier | JCR制药股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| US-20190040446-A1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | GODO SHUSEI CO., LTD. (JP) | 2019-02-07 | — | — | US | disclosed |
| EP-2687598-B1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | GODO SHUSEI KK (JP) | 2017-02-15 | — | — | EP | disclosed |
| US-20170029865-A1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | GODO SHUSEI CO., LTD. (JP) | 2017-02-02 | — | — | US | disclosed |
| US-20140087404-A1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | GODO SHUSEI CO., LTD. (JP) | 2014-03-27 | — | — | US | disclosed |
| EP-2687598-A1 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY | Godo Shusei Co., Ltd. (JP) | 2014-01-22 | — | — | EP | disclosed |