Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.33 |
| ▸ | NPC1 | O15118 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 6/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15418946 | 0.83 | PIK3CA (0.36) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL1733976 | 0.82 | PTGS1 (0.46) | ALDH1A1ALDH1A3KDM4EEGLN1CYP2C9 | |
| SCHEMBL1733303 | 0.78 | ALDH1A1 (0.38) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL1733882 | 0.75 | LRRK2 (0.40) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL1733988 | 0.75 | MAP3K5 (0.51) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL15418882 | 0.74 | ALDH1A1 (0.37) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL1735826 | 0.74 | ADORA2A (0.59) | ALDH1A1ALDH1A3KDM4ENPC1RAB9A | |
| SCHEMBL1733971 | 0.74 | NR4A2 (0.59) | ALDH1A1ALDH1A3EGLN1CYP2C9NR4A2 | |
| SCHEMBL3767499 | 0.74 | KDM4E (0.54) | ALDH1A1KDM4ENPC1RAB9APOLB | |
| SCHEMBL3771146 | 0.74 | NR4A2 (0.64) | NPC1RAB9AEGLN1CYP2C9NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |