Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.57 |
| ▸ | PGR | P06401 | 5/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542061 | 0.82 | NR3C1 (0.55) | NR3C1PGRCYP11B2SMO | |
| SCHEMBL27170733 | 0.81 | NR3C1 (0.67) | NR3C1PGRCYP11B2 | |
| SCHEMBL25230008 | 0.80 | NR3C1 (0.57) | NR3C1PGRCYP11B2 | |
| SCHEMBL25370177 | 0.79 | NR3C1 (0.47) | NR3C1PGRCYP11B2 | |
| SCHEMBL29493807 | 0.79 | NR3C1 (0.47) | NR3C1PGRCYP11B2 | |
| SCHEMBL1363835 | 0.79 | NR3C1 (0.57) | NR3C1PGRSMO | |
| SCHEMBL441369 | 0.79 | NR3C1 (0.57) | NR3C1PGRCYP11B2MAPK1 | |
| SCHEMBL1541841 | 0.79 | ALDH1A1 (0.54) | NR3C1PGRCYP11B2 | |
| SCHEMBL14765169 | 0.77 | NR3C1 (0.51) | NR3C1PGRCYP11B2 | |
| SCHEMBL3011613 | 0.77 | NR3C1 (0.62) | NR3C1PGRCYP11B2SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112299-A1 | TETRACYCLIC COMPOUND | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-05-12 | — | — | US | disclosed |
| EP-2308880-A1 | TETRACYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112299-A1 | TETRACYCLIC COMPOUND | REN, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, LPXN | NR3C1 236/4885PGR 1128/4885CYP11B2 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.