Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.40 |
| ▸ | KDM1A | O60341 | 7/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15421008 | 0.89 | SLC34A2 (0.43) | SLC34A2HDAC1KDM1AROCK2ROCK1 | |
| SCHEMBL46688 | 0.87 | SLC34A2 (0.53) | SLC34A2HDAC1KDM1ABRAFNR1H4 | |
| SCHEMBL39885 | 0.86 | SLC34A2 (0.48) | SLC34A2HDAC1KDM1AROCK2ROCK1 | |
| SCHEMBL15421009 | 0.84 | SLC34A2 (0.41) | SLC34A2HDAC1KDM1AROCK2ROCK1 | |
| SCHEMBL19580004 | 0.81 | SLC34A2 (0.52) | SLC34A2HDAC1KDM1AROCK2ROCK1 | |
| SCHEMBL19579946 | 0.80 | SLC34A2 (0.51) | SLC34A2HDAC1KDM1AALK | |
| SCHEMBL40026 | 0.79 | KDM1A (0.47) | SLC34A2HDAC1KDM1AROCK2ROCK1 | |
| SCHEMBL15432465 | 0.79 | SLC34A2 (0.49) | SLC34A2HDAC1KDM1AROCK2ROCK1 | |
| SCHEMBL39722 | 0.78 | SLC34A2 (0.57) | SLC34A2ROCK2ROCK1BRAF | |
| SCHEMBL19579952 | 0.78 | SLC34A2 (0.49) | SLC34A2HDAC1KDM1AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9301951-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150164876-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. | 2015-06-18 | — | — | US | disclosed |
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-20140023611-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150164876-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | SLC34A2, SLC34A1, SLC10A2 | SLC34A2 1/4885HDAC1 2715/4885KDM1A 4426/4885 |
| US-20140023611-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | SLC10A2, SLC34A2, SLC34A3 | SLC34A2 2/4885HDAC1 3309/4885KDM1A 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.