SCHEMBL15426344

SCHEMBL15426344

CSc1ccccc1-c1nc2cc(C)ccc2n1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACSS2 Q9NR19 1/20 0.46
KDM4E B2RXH2 5/20 0.44
HSD17B10 Q99714 1/20 0.44
ALDH1A1 P00352 3/20 0.43
HPGD P15428 3/20 0.43
CYP1A2 P05177 1/20 0.43
AGPAT2 O15120 1/20 0.43
NLRP3 Q96P20 1/20 0.43
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
NR1I2 O75469 1/20 0.40
AHR P35869 1/20 0.40
NPC1 O15118 5/20 0.40
RAB9A P51151 5/20 0.40
MAPT P10636 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
FGFR1 P11362 1/20 0.39
HTR3E A5X5Y0 1/20 0.38
HTR3B O95264 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10333891 0.86 KDM4E (0.60) KDM4EHSD17B10ALDH1A1HPGDCYP1A2
SCHEMBL10334140 0.85 MEN1 (0.51) KDM4EHSD17B10ALDH1A1HPGDMEN1
SCHEMBL15426338 0.85 NLRP3 (0.46) ACSS2KDM4EHSD17B10ALDH1A1HPGD
SCHEMBL10334062 0.83 KDM4E (0.44) KDM4EHSD17B10ALDH1A1HPGDCYP1A2
SCHEMBL15412348 0.83 PDE2A (0.46) KDM4EHSD17B10ALDH1A1HPGDCYP1A2
SCHEMBL10248930 0.82 SMN1; SMN2 (0.45) ACSS2KDM4EHSD17B10ALDH1A1HPGD
SCHEMBL15426254 0.79 KDM4E (0.39) KDM4EALDH1A1HPGDCYP1A2KMT2A
SCHEMBL12354514 0.78 ACSS2 (0.47) ACSS2KDM4EHSD17B10ALDH1A1HPGD
SCHEMBL10333262 0.78 KDM4E (0.47) KDM4EHSD17B10ALDH1A1HPGDCYP1A2
SCHEMBL14699735 0.77 AGPAT2 (0.49) ACSS2KDM4EHSD17B10ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 ACSS2 3015/4885KDM4E 2981/4885HSD17B10 1339/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 ACSS2 2897/4885KDM4E 2968/4885HSD17B10 1343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.