SCHEMBL15426347

SCHEMBL15426347

CC[S+]([O-])c1ccccc1-c1nc2cc(C)cc(Cl)c2n1C

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 3/20 0.33
PTGES O14684 1/20 0.33
DHODH Q02127 1/20 0.33
DPP8 Q6V1X1 2/20 0.32
HSD11B1 P28845 1/20 0.32
KDM4E B2RXH2 3/20 0.32
LMNA P02545 1/20 0.32
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15426351 0.86 DHODH (0.33) DHODH
SCHEMBL9958662 0.86 HSD11B1 (0.36) HSD11B1
SCHEMBL15426340 0.80 NLRP3 (0.44) KDM4EALDH1A1CYP1A2HPGD
SCHEMBL15412909 0.78 BRD4 (0.38) KDM4ELMNACYP1A2
SCHEMBL20708516 0.78 HSD11B1 (0.35) HSD11B1
SCHEMBL15426346 0.76 HSD11B1 (0.39) DPP4PTGESDHODHDPP8HSD11B1
SCHEMBL15426348 0.75 HSD11B1 (0.41) DPP4PTGESDHODHDPP8HSD11B1
SCHEMBL9958651 0.75 HSD11B1 (0.33) HSD11B1
SCHEMBL15412793 0.74 AKT1 (0.38) KDM4E
SCHEMBL15426396 0.73 AGTR1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 DPP4 4167/4885PTGES 4199/4885DHODH 4073/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 DPP4 4101/4885PTGES 4200/4885DHODH 3937/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.