SCHEMBL15426360

SCHEMBL15426360

CCSc1ccccc1-c1nc2cc(C)ccc2o1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.56
RAB9A P51151 10/20 0.56
NPC1 O15118 9/20 0.56
HPGD P15428 8/20 0.56
SMN1; SMN2 Q16637 8/20 0.56
CASP3 P42574 5/20 0.56
SENP7 Q9BQF6 5/20 0.56
SENP6 Q9GZR1 5/20 0.56
SENP8 Q96LD8 4/20 0.56
POLB P06746 2/20 0.56
ALDH1A1 P00352 9/20 0.51
TP53 P04637 8/20 0.51
HSD17B10 Q99714 7/20 0.51
MAPT P10636 8/20 0.48
TSHR P16473 2/20 0.48
MAPK1 P28482 1/20 0.48
NFKB1 P19838 3/20 0.47
NFKB2 Q00653 3/20 0.47
RELA Q04206 3/20 0.47
GAA P10253 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15426357 0.85 KDM4E (0.60) KDM4ERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL16746514 0.85 NPC1 (0.46) KDM4ERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL4544397 0.84 KDM4E (0.48) KDM4ERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL9952587 0.83 UTRN (0.45) KDM4ERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL18624695 0.82 NPC1 (0.43) KDM4ERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL16803691 0.81 ALDH1A1 (0.51) KDM4ERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL16746513 0.81 KDM4E (0.45) KDM4ERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL15616835 0.81 NPC1 (0.43) KDM4ERAB9ANPC1HPGDSMN1; SMN2
SCHEMBL15426363 0.80 NPC1 (0.45) KDM4ERAB9ANPC1CASP3SENP7
SCHEMBL14148310 0.79 RAB9A (0.73) KDM4ERAB9ANPC1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-05-28 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 KDM4E 2981/4885RAB9A 694/4885NPC1 2008/4885
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SFXN1, OSR1, PIR KDM4E 1144/4885RAB9A 1932/4885NPC1 2748/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 KDM4E 2968/4885RAB9A 697/4885NPC1 2099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.