SCHEMBL15426449

SCHEMBL15426449

CCSc1cc(C(F)(F)F)ccc1-c1nc2cc(C)ccc2n1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 1/20 0.42
PIK3CB P42338 1/20 0.42
PIK3CG P48736 1/20 0.42
AGPAT2 O15120 2/20 0.42
ACSS2 Q9NR19 1/20 0.39
KDM4E B2RXH2 2/20 0.37
HSD17B10 Q99714 1/20 0.37
DDR1 Q08345 1/20 0.36
MAPT P10636 1/20 0.36
NLRP3 Q96P20 1/20 0.36
MCHR1 Q99705 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
PDE2A O00408 3/20 0.35
P2RX3 P56373 1/20 0.35
TLR8 Q9NR97 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.34
HPGD P15428 1/20 0.34
CNR2 P34972 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15427237 0.87 AGPAT2 (0.40) PIK3CAPIK3CBPIK3CGAGPAT2KDM4E
SCHEMBL9959582 0.85 AGPAT2 (0.44) PIK3CAPIK3CBPIK3CGAGPAT2KDM4E
SCHEMBL15426411 0.82 POLB (0.41) AGPAT2DDR1MAPTCYP1A2PDE10A
SCHEMBL166988 0.82 AGPAT2 (0.42) PIK3CAPIK3CBPIK3CGAGPAT2KDM4E
SCHEMBL15868312 0.82 POLB (0.37) PIK3CAPIK3CBPIK3CGAGPAT2ACSS2
SCHEMBL21925102 0.81 DDR1 (0.35) AGPAT2DDR1PDE2AALDH1A1CYP1A2
SCHEMBL15426497 0.81 HSD11B1 (0.49) PIK3CAPIK3CBPIK3CGAGPAT2ACSS2
SCHEMBL15426338 0.81 NLRP3 (0.46) AGPAT2ACSS2KDM4EHSD17B10MAPT
SCHEMBL21590008 0.79 AGPAT2 (0.40) PIK3CAPIK3CBPIK3CGAGPAT2KDM4E
SCHEMBL14678088 0.79 POLB (0.40) PIK3CAPIK3CBPIK3CGAGPAT2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 PIK3CA 4291/4885PIK3CB 4032/4885PIK3CG 4118/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 PIK3CA 4183/4885PIK3CB 3934/4885PIK3CG 4024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.