Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15411056 | 0.79 | FAAH (0.44) | FAAHNCF1KDM4EPIK3CDLMNA | |
| SCHEMBL15411077 | 0.78 | PIK3CD (0.43) | FAAHNCF1PIK3CATHRBPIK3CB | |
| SCHEMBL15412031 | 0.78 | PIK3CD (0.43) | FAAHNCF1PIK3CATHRBPIK3CB | |
| SCHEMBL15410910 | 0.78 | PIK3CD (0.43) | FAAHNCF1PIK3CATHRBPIK3CB | |
| SCHEMBL15426759 | 0.72 | KDM4E (0.36) | KDM4EPIK3CBLMNAPOLBALDH1A1 | |
| SCHEMBL28246786 | 0.69 | NCF1 (0.41) | NCF1CHEK1AURKADAPK3JAK2 | |
| SCHEMBL24659682 | 0.66 | KDM1A (0.62) | FAAHPIK3CALRRK2KDM4EPIK3CG | |
| SCHEMBL18029065 | 0.65 | ATR (0.46) | NCF1KDM4EATRLMNAALDH1A1 | |
| SCHEMBL15362274 | 0.65 | FAAH (0.54) | FAAHPIK3CAKDM4EPIK3CBPIK3CD | |
| SCHEMBL7527390 | 0.65 | MAPT (0.48) | FAAHPIK3CAKDM4EPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014011568-A1 | AZAINDOLE DERIVATIVES WHICH ACT AS PI3K INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-01-16 | — | — | WO | disclosed |