SCHEMBL15427217

SCHEMBL15427217

Cn1c(-c2c(F)cccc2F)nc2cc(C(F)(F)F)cnc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ F7 P08709 1/20 0.38
▸ F3 P13726 1/20 0.38
▸ PDE2A O00408 3/20 0.37
▸ PDE10A Q9Y233 3/20 0.37
▸ GAA P10253 2/20 0.37
▸ ATM Q13315 1/20 0.37
▸ ALDH1A1 P00352 4/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ MAPT P10636 1/20 0.35
▸ NPY1R P25929 1/20 0.35
▸ NPY2R P49146 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ MAT2A P31153 1/20 0.35
▸ GRIN1 Q05586 3/20 0.35
▸ GRIN2B Q13224 3/20 0.35
▸ KDM4E B2RXH2 2/20 0.34
▸ SCN9A Q15858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10281008 0.92 POLB (0.43) POLBL3MBTL1F7F3PDE2A
SCHEMBL15427216 0.92 L3MBTL1 (0.42) POLBL3MBTL1PDE2APDE10AGAA
SCHEMBL15426504 0.91 POLB (0.37) POLBL3MBTL1F7F3PDE2A
SCHEMBL15427235 0.90 POLB (0.36) POLBL3MBTL1F7F3PDE2A
SCHEMBL10280743 0.90 POLB (0.42) POLBL3MBTL1PDE2APDE10AMAPT
SCHEMBL15427218 0.88 POLB (0.46) POLBL3MBTL1PDE2APDE10AGAA
SCHEMBL10280742 0.86 HSD11B1 (0.47) POLBL3MBTL1PDE2APDE10AGAA
SCHEMBL15427219 0.86 POLB (0.44) POLBPDE2APDE10AALDH1A1MEN1
SCHEMBL9953426 0.86 PDE2A (0.49) POLBL3MBTL1PDE2APDE10AGAA
SCHEMBL20708636 0.84 POLB (0.41) POLBL3MBTL1PDE2APDE10AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2655337-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2016-11-23 — — EP disclosed
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 — — US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 — — US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 — — US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 POLB 4715/4885L3MBTL1 31/4885F7 207/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 POLB 4737/4885L3MBTL1 33/4885F7 221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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