SCHEMBL15427235

SCHEMBL15427235

Cn1c(-c2c(F)cccc2F)nc2cc(C(F)(F)C(F)(F)F)cnc21

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.36
▸ PDE10A Q9Y233 3/20 0.33
▸ PDE2A O00408 2/20 0.33
▸ WEE1 P30291 2/20 0.33
▸ F7 P08709 1/20 0.32
▸ F3 P13726 1/20 0.32
▸ ABL1 P00519 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.31
▸ USP2 O75604 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ CYP1A2 P05177 1/20 0.31
▸ CYP3A4 P08684 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ CLK4 Q9HAZ1 1/20 0.31
▸ CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15427217 0.90 POLB (0.45) POLBPDE10APDE2AWEE1F7
SCHEMBL15426504 0.89 POLB (0.37) POLBPDE10APDE2AWEE1F7
SCHEMBL15427216 0.82 L3MBTL1 (0.42) POLBPDE10APDE2AWEE1L3MBTL1
SCHEMBL10281008 0.82 POLB (0.43) POLBPDE10APDE2AF7F3
SCHEMBL15426491 0.81 AKT1 (0.38) PDE10APDE2AWEE1ABL1USP2
SCHEMBL30205924 0.81 POLB (0.35) POLBUSP2ALDH1A1CYP1A2CYP3A4
SCHEMBL27172664 0.81 POLB (0.35) POLBUSP2ALDH1A1CYP1A2CYP3A4
SCHEMBL10280743 0.80 POLB (0.42) POLBPDE10APDE2AL3MBTL1TSHR
SCHEMBL10280710 0.79 CYP11B2 (0.30) F7F3CYP11B2
SCHEMBL19299830 0.78 POLB (0.42) POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2655337-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2016-11-23 — — EP disclosed
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 — — US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 — — US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 — — US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 POLB 4715/4885PDE10A 3812/4885PDE2A 3467/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 POLB 4737/4885PDE10A 3725/4885PDE2A 3420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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