Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | CCR5 | P51681 | 3/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGAV | P06756 | 1/20 | 0.49 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15427591 | 0.88 | NR1H4 (0.64) | NR1H4LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17664553 | 0.87 | NR1H4 (0.74) | NR1H4NPC1RAB9ASMN1; SMN2CCR5 | |
| SCHEMBL13027010 | 0.82 | NR1H4 (0.60) | NR1H4LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13719791 | 0.81 | NPC1 (0.70) | LMNANPC1RAB9ASMN1; SMN2THRB | |
| SCHEMBL15427593 | 0.80 | LMNA (0.60) | LMNANPC1RAB9ASMN1; SMN2THRB | |
| SCHEMBL15427597 | 0.79 | THRB (0.66) | LMNANPC1RAB9ASMN1; SMN2FFAR1 | |
| SCHEMBL13719742 | 0.79 | NPC1 (0.74) | LMNANPC1RAB9ASMN1; SMN2THRB | |
| SCHEMBL1232960 | 0.78 | NR1H4 (0.71) | NR1H4NPC1RAB9ACCR5FFAR1 | |
| SCHEMBL9237926 | 0.78 | NR1H4 (0.70) | NR1H4LMNACCR5MEN1KMT2A | |
| SCHEMBL9236055 | 0.78 | NR1H4 (0.70) | NR1H4LMNACCR5FFAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633335-B2 | Retinoid prodrug compound | Research Founation Itsuu Laboratory (JP) | 2014-01-21 | — | — | US | disclosed |