Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 9/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.76 |
| ▸ | RAB9A | P51151 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | YAP1 | P46937 | 1/20 | 0.76 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.76 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428378 | 0.90 | GPX4 (0.75) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL27264584 | 0.88 | GPX4 (0.75) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL31012414 | 0.87 | GPX4 (0.69) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL15428380 | 0.87 | GPX4 (1.00) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL23821197 | 0.81 | GPX4 (0.68) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL27264585 | 0.80 | GPX4 (0.74) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL23820061 | 0.79 | GPX4 (0.60) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL1887127 | 0.79 | YAP1 (0.66) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL21966275 | 0.78 | GPX4 (0.85) | GPX4NPSR1NPC1RAB9ALMNA | |
| SCHEMBL29992306 | 0.78 | GPX4 (0.78) | GPX4NPSR1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695133-B2 | Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150175558-A1 | QUINAZOLINONE-BASED ONCOGENIC-RAS-SELECTIVE LETHAL COMPOUNDS AND THEIR USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-25 | — | — | US | disclosed |
| WO-2014011973-A2 | QUINAZOLINONE-BASED ONCOGENIC-RAS-SELECTIVE LETHAL COMPOUNDS AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175558-A1 | QUINAZOLINONE-BASED ONCOGENIC-RAS-SELECTIVE LETHAL COMPOUNDS AND THEIR USE | KRAS, KEAP1, NRAS | GPX4 4/4885NPSR1 3762/4885NPC1 3378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.