Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14627262 | 0.85 | SIGMAR1 (0.46) | MAPTKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL20384109 | 0.83 | MAPT (0.37) | MAPTKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL14594798 | 0.78 | MAPT (0.36) | MAPTKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL20384101 | 0.72 | SIGMAR1 (0.35) | MAPTKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL23508979 | 0.72 | SIGMAR1 (0.35) | MAPTKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL15428837 | 0.71 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL6593632 | 0.69 | — | — | |
| SCHEMBL14594813 | 0.67 | SIGMAR1 (0.41) | SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21271537 | 0.66 | NCF1 (0.43) | MAPTKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL2279449 | 0.66 | NCF1 (0.43) | MAPTKDM4EMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140171454-A1 | Substituted Pyrrolo[2,3-d]pyrimidines as Inhibitors of Protein Kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-19 | — | — | US | disclosed |
| US-8633205-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171454-A1 | Substituted Pyrrolo[2,3-d]pyrimidines as Inhibitors of Protein Kinases | PRKDC, DCK, CDK2 | MAPT 1444/4885KDM4E 1255/4885MEN1 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.