Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318756 | 0.90 | NR1H4 (0.55) | MMP13KMT2ASMN1; SMN2NR1H4EPHX2 | |
| SCHEMBL15428857 | 0.90 | CHRM3 (0.54) | MMP13NR1H4EPHX2NR4A1NR4A2 | |
| SCHEMBL15428870 | 0.89 | KMT2A (0.67) | MMP13KMT2ASMN1; SMN2NR1H4EPHX2 | |
| SCHEMBL15428856 | 0.89 | NR1H4 (0.60) | MMP13KMT2ASMN1; SMN2NR1H4EPHX2 | |
| SCHEMBL15428868 | 0.88 | SMN1; SMN2 (0.53) | MMP13KMT2ASMN1; SMN2NR1H4EPHX2 | |
| SCHEMBL15428860 | 0.88 | KDM4E (0.53) | MMP13KMT2ASMN1; SMN2NR1H4EPHX2 | |
| SCHEMBL15428862 | 0.85 | CHRM3 (0.57) | KMT2ASMN1; SMN2NR1H4EPHX2NR4A1 | |
| SCHEMBL15428864 | 0.83 | MMP13 (0.65) | MMP13KMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL15428881 | 0.82 | PPARG (0.49) | MMP13NR1H4EPHX2NR4A1NR4A2 | |
| SCHEMBL15428879 | 0.82 | POLB (0.58) | MMP13KMT2ASMN1; SMN2NR1H4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346831-B1 | HETEROARYL DIAMIDE COMPOUNDS USEFUL AS MMP-13 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2015-01-07 | — | — | EP | disclosed |
| US-8637550-B2 | Heteroaryl diamide compounds useful as MMP-13 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-28 | — | — | US | disclosed |