SCHEMBL15433215

SCHEMBL15433215

CC/C(F)=C(\F)c1ccc(-c2ccc(-c3cc(F)c(C(F)(F)F)c(F)c3)c(F)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 8/20 0.39
AKR1C3 P42330 3/20 0.35
AKR1C2 P52895 3/20 0.35
APP P05067 1/20 0.34
RARB P10826 1/20 0.33
ALOX5AP P20292 1/20 0.32
FEN1 P39748 1/20 0.32
PPARD Q03181 1/20 0.31
AKR1B10 O60218 1/20 0.31
AKR1C4 P17516 1/20 0.31
AKR1C1 Q04828 1/20 0.31
PDK2 Q15119 1/20 0.31
RXRA P19793 1/20 0.31
RXRB P28702 1/20 0.31
RXRG P48443 1/20 0.31
KDM4E B2RXH2 1/20 0.31
LMNA P02545 1/20 0.31
HSD17B10 Q99714 1/20 0.31
FASN P49327 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15433429 0.99 KIF11 (0.38) KIF11AKR1C3AKR1C2APPRARB
SCHEMBL15433428 0.90 KIF11 (0.37) KIF11AKR1C3AKR1C2APPRARB
SCHEMBL15433573 0.88 RARB (0.34) KIF11RARBPPARD
SCHEMBL15433276 0.87 KDM1A (0.34) AKR1C3AKR1C2PDK2
SCHEMBL15433387 0.86 RARB (0.36) KIF11AKR1C3AKR1C2APPRARB
SCHEMBL15433170 0.86 RARB (0.36) KIF11AKR1C3AKR1C2APPRARB
SCHEMBL15433179 0.86 RARB (0.36) KIF11AKR1C3AKR1C2APPRARB
SCHEMBL15433435 0.86 AKR1C3 (0.33) AKR1C3AKR1C2APPRARBALOX5AP
SCHEMBL15433497 0.85 KIF11 (0.38) KIF11RARBRXRARXRBRXRG
SCHEMBL15433533 0.85 MAOB (0.40) PPARDRXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8956551-B2 Liquid crystal compound having fluorovinyl group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-02-17 US disclosed
US-8956551-B2 Liquid crystal compound having fluorovinyl group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-02-17 US disclosed
US-20140021406-A1 LIQUID CRYSTAL COMPOUND HAVING FLUOROVINYL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-01-23 US disclosed
US-20140021406-A1 LIQUID CRYSTAL COMPOUND HAVING FLUOROVINYL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-01-23 US disclosed