SCHEMBL15433428

SCHEMBL15433428

CCC/C(F)=C(\F)c1ccc(-c2ccc(-c3ccc(-c4cc(F)c(C(F)(F)F)c(F)c4)c(F)c3)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 5/20 0.37
RARB P10826 1/20 0.34
AKR1C3 P42330 2/20 0.34
AKR1C2 P52895 2/20 0.34
RORC P51449 4/20 0.33
APP P05067 1/20 0.33
PPARD Q03181 1/20 0.32
RORA P35398 1/20 0.32
NR1H4 Q96RI1 1/20 0.32
NPC1 O15118 2/20 0.31
RAB9A P51151 2/20 0.31
HPGD P15428 2/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
ALOX5AP P20292 2/20 0.30
FEN1 P39748 2/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15433498 0.94 RARB (0.41) KIF11RARBAKR1C3AKR1C2
SCHEMBL15433215 0.90 KIF11 (0.39) KIF11RARBAKR1C3AKR1C2APP
SCHEMBL15433429 0.89 KIF11 (0.38) KIF11RARBAKR1C3AKR1C2APP
SCHEMBL15433835 0.87 KIF11 (0.36) KIF11HPGDSMN1; SMN2L3MBTL1
SCHEMBL15433386 0.86 RARB (0.39) KIF11RARBRORCAPPRORA
SCHEMBL15433211 0.84 KIF11 (0.38) KIF11RARBRORC
SCHEMBL15433584 0.84 RARB (0.33) RARBALOX5APFEN1
SCHEMBL15433500 0.82 RARB (0.34) KIF11RARBMEN1ALDH1A1MAPT
SCHEMBL15433214 0.81 PDK2 (0.38) KIF11RARBAKR1C3AKR1C2APP
SCHEMBL15433468 0.81 FASN (0.37) RARBNPC1RAB9AHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8956551-B2 Liquid crystal compound having fluorovinyl group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-02-17 US disclosed
US-8956551-B2 Liquid crystal compound having fluorovinyl group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-02-17 US disclosed
US-20140021406-A1 LIQUID CRYSTAL COMPOUND HAVING FLUOROVINYL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-01-23 US disclosed
US-20140021406-A1 LIQUID CRYSTAL COMPOUND HAVING FLUOROVINYL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-01-23 US disclosed