Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428932 | 0.87 | ADORA2A (0.36) | BRD4TP53ALDH1A1USP2CYP1A2 | |
| SCHEMBL13074830 | 0.82 | HTR6 (0.39) | TP53RXFP1HTR6ALDH1A1CYP3A4 | |
| SCHEMBL7900338 | 0.81 | HTR6 (0.38) | TP53RXFP1HTR6ALDH1A1CYP3A4 | |
| SCHEMBL7906965 | 0.78 | KDM4E (0.39) | TP53RXFP1HTR6ALDH1A1CYP3A4 | |
| SCHEMBL7909715 | 0.78 | HTR6 (0.39) | TP53RXFP1HTR6ALDH1A1USP2 | |
| SCHEMBL7909713 | 0.78 | HTR6 (0.37) | TP53RXFP1HTR6ALDH1A1KMT2A | |
| SCHEMBL288637 | 0.77 | F2 (0.40) | BRD4ALPLALDH1A1USP2CYP1A2 | |
| SCHEMBL13074827 | 0.77 | HPGDS (0.44) | TP53RXFP1HTR6KDM4EPKM | |
| SCHEMBL7906969 | 0.77 | KDM4E (0.42) | TP53RXFP1HTR6ALDH1A1CYP1A2 | |
| SCHEMBL13074829 | 0.77 | HTR6 (0.38) | TP53RXFP1HTR6ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427434-B1 | PROCESS FOR PREPARING BROMO-SUBSTITUTED QUINOLINES | BOEHRINGER INGELHEIM INT (DE) | 2017-05-31 | — | — | EP | disclosed |
| US-8633320-B2 | Process for preparing bromo-substituted quinolines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-21 | — | — | US | disclosed |