Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | TLR2 | O60603 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19821998 | 0.78 | LMNA (0.36) | LMNATHRB | |
| SCHEMBL13681686 | 0.76 | ALDH1A1 (0.44) | LMNATHRB | |
| SCHEMBL15725702 | 0.71 | LMNA (0.36) | LMNATHRB | |
| SCHEMBL13681687 | 0.71 | DEGS1 (0.49) | LMNATHRB | |
| SCHEMBL13681690 | 0.69 | DEGS1 (0.48) | LMNATHRB | |
| SCHEMBL277842 | 0.68 | LMNA (0.43) | LMNA | |
| SCHEMBL13662405 | 0.68 | TLR2 (0.34) | LMNATDP1TLR2 | |
| SCHEMBL12514001 | 0.68 | EPHX1 (0.40) | LMNATLR2 | |
| SCHEMBL19821907 | 0.67 | LMNA (0.39) | LMNA | |
| SCHEMBL20334103 | 0.67 | ALDH1A1 (0.40) | LMNATLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9399070-B2 | Compositions comprising a polymeric reagent and a pharmacologically active agent | NEKTAR THERAPEUTICS (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150328331-A1 | Compositions Comprising a Polymeric Reagent and a Pharmacologically Active Agent | NEKTAR THERAPEUTICS (US) | 2015-11-19 | — | — | US | disclosed |
| US-8633277-B2 | Methods for forming polymer-drug conjugates | NEKTAR THERAPEUTICS (US) | 2014-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150328331-A1 | Compositions Comprising a Polymeric Reagent and a Pharmacologically Active Agent | PHOSPHO1, PAICS, FCGRT | LMNA 1599/4885TDP1 3688/4885THRB 4079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.