Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ASPH | Q12797 | 1/20 | 0.45 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.45 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22191322 | 0.85 | HPGD (0.72) | HPGDHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL22202128 | 0.83 | HPGD (0.70) | HPGDHTR7HDAC6HDAC3HDAC1 | |
| SCHEMBL14869380 | 0.78 | HTR7 (0.68) | HPGDHTR7SIGMAR1TMIGD3ADORA2A | |
| SCHEMBL15399488 | 0.77 | HPGD (0.60) | HPGDHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27873802 | 0.76 | HPGD (0.59) | HPGDSIGMAR1CTSC | |
| SCHEMBL4377382 | 0.74 | HTR7 (0.56) | HPGDHTR7TMIGD3ADORA2AADORA1 | |
| SCHEMBL22191357 | 0.74 | HDAC3 (0.60) | HPGDHTR7HDAC6HDAC3HDAC1 | |
| SCHEMBL11793049 | 0.74 | MAOB (0.62) | HPGDHDAC6SIGMAR1MAOB | |
| SCHEMBL10502959 | 0.73 | HPGD (0.55) | HPGDHTR7HDAC6HDAC3HDAC1 | |
| SCHEMBL20495335 | 0.72 | HDAC3 (0.63) | HPGDHDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687507-B1 | NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND | TAISHO PHARMACEUTICAL CO LTD (JP) | 2016-03-09 | — | — | EP | disclosed |
| US-9035059-B2 | Nitrogen-containing condensed heterocyclic compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-05-19 | — | — | US | disclosed |
| EP-2687507-A1 | NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-01-22 | — | — | EP | disclosed |