Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22191322 | 0.85 | HPGD (0.72) | HPGDHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL15435182 | 0.83 | HPGD (0.70) | HPGDHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL11565739 | 0.81 | RAB9A (0.60) | HPGDHDAC6HDAC1MEN1KMT2A | |
| SCHEMBL19145368 | 0.80 | VNN1 (0.57) | HPGDHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL10502959 | 0.79 | HPGD (0.55) | HPGDHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL15399488 | 0.77 | HPGD (0.60) | HPGDHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL11566177 | 0.76 | RAB9A (0.59) | HPGDHDAC6HDAC1KMT2ASIGMAR1 | |
| SCHEMBL27873802 | 0.76 | HPGD (0.59) | HPGDSIGMAR1 | |
| SCHEMBL11563635 | 0.75 | RAB9A (0.58) | HPGDHDAC6KMT2ASIGMAR1KDM4E | |
| SCHEMBL10502861 | 0.75 | HPGD (0.50) | HPGDHDAC3HDAC1HDAC2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142486-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2020-07-09 | — | — | WO | disclosed |