SCHEMBL15435308

SCHEMBL15435308

COc1cc(F)ccc1NS(=O)(=O)c1ccc2c(c1)CCN(Cc1ccc(C(F)(F)F)cc1)C2

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MOGAT2 Q3SYC2 19/20 0.57
KMT2A Q03164 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16715640 0.89 MOGAT2 (0.68) MOGAT2
SCHEMBL15400847 0.85 MOGAT2 (0.74) MOGAT2
SCHEMBL15435247 0.84 MOGAT2 (0.69) MOGAT2KMT2A
SCHEMBL15435269 0.80 MOGAT2 (0.82) MOGAT2
SCHEMBL15435213 0.79 MOGAT2 (0.81) MOGAT2
SCHEMBL16715525 0.79 MOGAT2 (0.79) MOGAT2
SCHEMBL15435209 0.78 MOGAT2 (0.63) MOGAT2KMT2A
SCHEMBL15435300 0.78 MOGAT2 (0.83) MOGAT2
SCHEMBL17565148 0.77 ACACB (0.55) MOGAT2KMT2A
SCHEMBL16715509 0.77 MOGAT2 (0.71) MOGAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9035059-B2 Nitrogen-containing condensed heterocyclic compound TAISHO PHARMACEUTICAL CO., LTD. (JP) 2015-05-19 US disclosed
US-9035059-B2 Nitrogen-containing condensed heterocyclic compound TAISHO PHARMACEUTICAL CO., LTD. (JP) 2015-05-19 US disclosed
EP-2687507-A1 NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND Taisho Pharmaceutical Co., Ltd. (JP) 2014-01-22 EP disclosed