Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | VEGFA | P15692 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 7/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 6/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.30 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15333307 | 0.77 | PKM (0.45) | EGLN1VEGFANPC1KMT2ARAB9A | |
| SCHEMBL20386728 | 0.77 | EGLN1 (0.53) | EGLN1VEGFANPC1KMT2ARAB9A | |
| SCHEMBL25433288 | 0.76 | ELANE (0.43) | ELANEPARP1EGLN1VEGFARAB9A | |
| SCHEMBL13923526 | 0.76 | ELANE (0.46) | ELANEPARP1EGLN1VEGFAKMT2A | |
| SCHEMBL15803813 | 0.76 | ELANE (0.37) | ELANEPARP1EGLN1VEGFAKMT2A | |
| SCHEMBL20697298 | 0.73 | PARP1 (0.46) | ELANEPARP1EGLN1VEGFANPC1 | |
| SCHEMBL15804049 | 0.73 | BRD4 (0.54) | EGLN1VEGFANPC1RAB9AALDH1A1 | |
| SCHEMBL15804040 | 0.72 | ELANE (0.46) | ELANEPARP1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL197253 | 0.72 | ELANE (0.49) | ELANEPARP1KMT2ARAB9AMEN1 | |
| SCHEMBL7021949 | 0.72 | ELANE (0.49) | ELANEPARP1EGLN1VEGFAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3405477-B1 | INHIBITORS OF TRANSGLUTAMINASES | ZEDIRA GMBH (DE) | 2023-06-07 | — | — | EP | disclosed |
| US-11072634-B2 | Inhibitors of transglutaminases | ZEDIRA GMBH (DE) | 2021-07-27 | — | — | US | disclosed |
| EP-2687511-A1 | Pyridinone derivatives as tissue transglutaminase inhibitors | Zedira GmbH (DE) | 2014-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072634-B2 | Inhibitors of transglutaminases | TGM2, TGM3, TGM1 | ELANE 1392/4885PARP1 2569/4885EGLN1 1745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.