Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15436573 | 0.86 | POLB (0.45) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL15436505 | 0.79 | CSF1R (0.39) | KMT2ALMNA | |
| SCHEMBL15436746 | 0.77 | CSF1R (0.41) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL15436493 | 0.77 | CSF1R (0.40) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL15436669 | 0.76 | CSF1R (0.41) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL19868327 | 0.74 | CREBBP (0.35) | HTTSMN1; SMN2 | |
| SCHEMBL15436762 | 0.74 | CSF1R (0.41) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL15436835 | 0.72 | CSF1R (0.43) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL13147790 | 0.72 | CSF1R (0.52) | — | |
| SCHEMBL1863248 | 0.70 | PIN1 (0.39) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687516-A1 | Inhibitors of C-FMS Kinase | Janssen Pharmaceutica N.V. (BE) | 2014-01-22 | — | — | EP | disclosed |