Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12494794 | 0.82 | CYP1A2 (0.60) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL12495269 | 0.79 | CYP1A2 (0.76) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL12495017 | 0.77 | SMN1; SMN2 (0.73) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL15439647 | 0.75 | CYP1A2 (0.53) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL12495068 | 0.75 | CYP2C19 (1.00) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL15440478 | 0.74 | BCAT1 (0.53) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL3983956 | 0.74 | BCAT1 (0.53) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL15439768 | 0.74 | CYP1A2 (0.72) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL15439186 | 0.74 | CYP1A2 (0.52) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A | |
| SCHEMBL15444581 | 0.73 | CYP1A2 (0.51) | CYP1A2CYP2C19SMN1; SMN2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479771-B2 | Pyridazinone and pyridone compounds | BIOTIE THERAPIES CORPORATION (FI) | 2019-11-19 | — | — | US | disclosed |
| US-20180029995-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | BIOTIE THERAPIES CORPORATION (FI) | 2018-02-01 | — | — | US | disclosed |
| US-20180029995-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | BIOTIE THERAPIES CORPORATION (FI) | 2018-02-01 | — | — | US | disclosed |
| US-9815795-B2 | Pyridazinone and pyridone compounds | BIOTIE THERAPIES CORPORATION (FI) | 2017-11-14 | — | — | US | disclosed |
| US-9815795-B2 | Pyridazinone and pyridone compounds | BIOTIE THERAPIES CORPORATION (FI) | 2017-11-14 | — | — | US | disclosed |
| US-20160244414-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | BIOTIE THERAPIES CORPORATION (FI) | 2016-08-25 | — | — | US | disclosed |
| US-9371290-B2 | Pyridazinone compounds | BIOTIE THERAPIES CORPORATION (FI) | 2016-06-21 | — | — | US | disclosed |
| US-20140024648-A1 | NEW PYRIDAZINONE AND PYRIDONE COMPOUNDS | BIOTIE THERAPIES CORPORATION (FI) | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244414-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | XDH, PNPO, PDXK | CYP1A2 14/4885CYP2C19 11/4885SMN1; SMN2 3199/4885 |
| US-20140024648-A1 | NEW PYRIDAZINONE AND PYRIDONE COMPOUNDS | XDH, PNPO, PDXK | CYP1A2 20/4885CYP2C19 23/4885SMN1; SMN2 3379/4885 |
| US-20180029995-A1 | PYRIDAZINONE AND PYRIDONE COMPOUNDS | XDH, PNPO, PDXK | CYP1A2 14/4885CYP2C19 11/4885SMN1; SMN2 3199/4885 |
| US-10479771-B2 | Pyridazinone and pyridone compounds | XDH, PNPO, PDXK | CYP1A2 14/4885CYP2C19 11/4885SMN1; SMN2 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.