Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.45 |
| ▸ | PRKCI | P41743 | 2/20 | 0.44 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15308511 | 0.77 | LRRK2 (0.47) | BRD4ATAD2IRAK4 | |
| SCHEMBL30698332 | 0.76 | BRD4 (0.50) | BRD4CHEK1PRKCIPRKCZRPS6KB1 | |
| SCHEMBL31227391 | 0.74 | BRD4 (0.60) | BRD4ATAD2PRKCIPRKCZRPS6KB1 | |
| SCHEMBL31227704 | 0.74 | BRD4 (0.54) | BRD4CHEK1ATAD2PRKCIIRAK4 | |
| SCHEMBL31227547 | 0.74 | RPS6KB1 (0.49) | BRD4CHEK1PRKCZRPS6KB1AURKA | |
| SCHEMBL30259588 | 0.73 | KDM4E (0.61) | BRD4PRKCZCDK2ROCK2ROCK1 | |
| SCHEMBL27877307 | 0.73 | CHEK1 (0.55) | BRD4CHEK1ATAD2PRKCIPRKCZ | |
| SCHEMBL31227336 | 0.73 | BRD4 (0.61) | BRD4CHEK1ATAD2PRKCIIL1B | |
| SCHEMBL15219316 | 0.73 | BRD4 (0.53) | BRD4ATAD2IL1BPRKCZIRAK4 | |
| SCHEMBL15440732 | 0.72 | PRKCZ (0.51) | PRKCIPRKCZCDK2IRAK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | PIM1, PIM2, PIM3 | BRD4 138/4885CHEK1 1068/4885ATAD2 3441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.