Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.44 |
| ▸ | CCNK | O75909 | 5/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.44 |
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | CDK9 | P50750 | 5/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CCNH | P51946 | 2/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1035615 | 0.91 | BRD4 (0.48) | BRD4RPS6KB1CHEK2PRKCICHEK1 | |
| SCHEMBL1035617 | 0.91 | BRD4 (0.48) | BRD4RPS6KB1CHEK2PRKCICHEK1 | |
| SCHEMBL19086792 | 0.81 | CYP1A2 (0.50) | BRD4AURKARPS6KB1PTPN11 | |
| SCHEMBL31227547 | 0.80 | RPS6KB1 (0.49) | BRD4PRKCZAURKARPS6KB1CHEK2 | |
| SCHEMBL30259588 | 0.78 | KDM4E (0.61) | BRD4PRKCZCCNT1CCNKCCNE1 | |
| SCHEMBL3727731 | 0.77 | PRKCZ (0.52) | PRKCZCDK2CHEK2CHEK1 | |
| SCHEMBL4705576 | 0.76 | IRAK4 (0.52) | PRKCZAURKARPS6KB1CDK7CCNH | |
| SCHEMBL15440530 | 0.76 | BRD4 (0.55) | BRD4PRKCZAURKARPS6KB1CDK2 | |
| SCHEMBL14672433 | 0.75 | MAPK3 (0.46) | PRKCZCCNT1CCNKCCNE1CDK2 | |
| SCHEMBL14672432 | 0.75 | MAPK3 (0.46) | PRKCZCCNT1CCNKCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540248-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023245123-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-12-21 | — | — | WO | disclosed |