Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 8/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.32 |
| ▸ | GLP1R | P43220 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15146939 | 0.95 | SIRT2 (0.39) | SIRT2HDAC4MEF2DSIRT1SIRT3 | |
| SCHEMBL15144370 | 0.90 | SIRT2 (0.42) | SIRT2HDAC4MEF2DSIRT1SIRT3 | |
| SCHEMBL11964062 | 0.85 | AKT1 (0.42) | SIRT2SIRT1SIRT3TPSAB1GLP1R | |
| SCHEMBL14755924 | 0.83 | AKT1 (0.41) | SIRT2SIRT1SIRT3TPSAB1GLP1R | |
| SCHEMBL11964063 | 0.80 | SIRT2 (0.38) | SIRT2SIRT1SIRT3TPSAB1GLP1R | |
| SCHEMBL14864110 | 0.78 | FOLH1 (0.38) | SIRT2HDAC4SIRT1TPSAB1POLB | |
| SCHEMBL18084214 | 0.77 | AKT1 (0.42) | SIRT2SIRT1SIRT3TPSAB1GLP1R | |
| SCHEMBL17488484 | 0.77 | AKT1 (0.40) | SIRT2SIRT1SIRT3GLP1R | |
| SCHEMBL14542727 | 0.77 | AKT1 (0.36) | SIRT2SIRT1POLBHSD17B10 | |
| SCHEMBL14864111 | 0.76 | FOLH1 (0.37) | SIRT2HDAC4TPSAB1POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8636994-B2 | Polymer-based compositions and conjugates of antimicrobial agents | NEKTAR THERAPEUTICS (US) | 2014-01-28 | — | — | US | disclosed |