Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28366619 | 0.85 | CA1 (0.52) | TDP1ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL14638953 | 0.84 | TPMT (0.41) | TDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL1702960 | 0.84 | MEN1 (0.44) | TDP1ALDH1A1MAPTLMNACES2 | |
| SCHEMBL27154482 | 0.84 | RAB9A (0.44) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL14638933 | 0.84 | CA1 (0.53) | MAPTLMNACES2CES1HDAC1 | |
| SCHEMBL926435 | 0.84 | HPGD (0.44) | ALDH1A1MAPTKDM4ELMNACES2 | |
| SCHEMBL545737 | 0.83 | TSHR (0.50) | TDP1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL28321122 | 0.82 | SMN1; SMN2 (0.45) | TDP1ALDH1A1MAPTGAALMNA | |
| SCHEMBL28470289 | 0.81 | ALDH1A1 (0.41) | TDP1ALDH1A1MAPTKDM4EGAA | |
| SCHEMBL13735831 | 0.81 | SMN1; SMN2 (0.47) | ALDH1A1MAPTLMNAHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110734441-B | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-09-04 | — | — | CN | claimed |
| CN-110734441-A | 3, 3' -pyrrolidine indole spiro-compound and preparation method and application thereof | 广州大学 | 2020-01-31 | — | — | CN | claimed |
| CN-104109108-A | Alpha-quaternary carbon contained alpha,beta-diamino acid derivatives, and cocatalytic preparation method and application thereof | UNIV EAST CHINA NORMAL | 2014-10-22 | — | — | CN | claimed |
| CN-104072449-A | Full-substituted tetrahydrofuran derivative as well as preparation method and application thereof | UNIV EAST CHINA NORMAL | 2014-10-01 | — | — | CN | claimed |
| CN-104059049-A | Benzo dioxy heterocyclic derivatives with optical activity and preparation method and application thereof | UNIV EAST CHINA NORMAL | 2014-09-24 | — | — | CN | claimed |
| CN-104058998-A | Alpha-amino and delta-hydroxyl adipic acid derivatives and preparation method and application thereof | UNIV EAST CHINA NORMAL | 2014-09-24 | — | — | CN | claimed |
| CN-103242209-A | Preparation method of alpha-amido, delta-hydroxyl adipic acid derivatives | UNIV EAST CHINA NORMAL | 2013-08-14 | — | — | CN | claimed |
| CN-103204833-A | Preparation method of fully-substituted tetrahydrofuran derivative | UNIV EAST CHINA NORMAL | 2013-07-17 | — | — | CN | claimed |
| CN-103204786-A | Co-catalyzing preparation method of alpha, betal-diamino acid derivative of alpha-quaternary carbon | UNIV EAST CHINA NORMAL | 2013-07-17 | — | — | CN | claimed |
| CN-117777127-A | Chiral tetrahydro-beta-carboline derivative and preparation method and application thereof | 中山大学 | 2024-03-29 | — | — | CN | disclosed |
| CN-116675658-A | Process for preparing gamma-vinylidene-butenoic acid lactones and/or benzofulvenes | 中北大学 | 2023-09-01 | — | — | CN | disclosed |
| CN-112898213-B | Polysubstituted 1, 3-diene supported ring compound and application thereof | 中国科学院上海药物研究所 | 2022-11-04 | — | — | CN | disclosed |
| CN-112898213-A | Polysubstituted 1, 3-diene supported ring compound and application thereof | 中国科学院上海药物研究所 | 2021-06-04 | — | — | CN | disclosed |
| CN-108658812-B | Alpha-alkoxy-alpha-nitrogen oxyacetate derivative and synthesis method and application thereof | 华东师范大学 | 2020-12-22 | — | — | CN | disclosed |
| US-20140249199-A1 | TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO | HEALTH RESEARCH, INC. (US) | 2014-09-04 | — | — | US | disclosed |
| EP-2689847-A1 | Methods for catalytic alkylation of nucleic acids | Universität Basel (CH) | 2014-01-29 | — | — | EP | disclosed |
| CN-103204833-A | Preparation method of fully-substituted tetrahydrofuran derivative | UNIV EAST CHINA NORMAL | 2013-07-17 | — | — | CN | disclosed |
| CN-103204786-A | Co-catalyzing preparation method of alpha, betal-diamino acid derivative of alpha-quaternary carbon | UNIV EAST CHINA NORMAL | 2013-07-17 | — | — | CN | disclosed |
| CN-102070510-B | 3-hydroxyindole derivatives and synthesis method and use thereof | UNIV EAST CHINA NORMAL | 2012-10-31 | — | — | CN | disclosed |
| CN-102070510-A | 3-hydroxyindole derivatives and synthesis method and use thereof | UNIV EAST CHINA NORMAL | 2011-05-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249199-A1 | TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO | TAB1, MAP3K1, MAP3K6 | TDP1 1139/4885ALDH1A1 3574/4885MAPT 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.