Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 13/20 | 0.80 |
| ▸ | FLT1 | P17948 | 13/20 | 0.80 |
| ▸ | EGFR | P00533 | 10/20 | 0.80 |
| ▸ | FLT4 | P35916 | 9/20 | 0.80 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.80 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.80 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.80 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | KIF5B | P33176 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zd-4190 Free Base SCHEMBL173259 | 0.89 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL14040728 | 0.89 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| Zd-4190 Free Base SCHEMBL29729304 | 0.89 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| Zd-4190 Free Base SCHEMBL29363192 | 0.88 | KDR (0.98) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL15445277 | 0.78 | EGFR (0.80) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5177296 | 0.77 | KDR (0.79) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5864534 | 0.75 | KDR (0.77) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL17520360 | 0.74 | KDR (0.83) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL5493929 | 0.74 | ENPP1 (0.64) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL7459925 | 0.74 | KDR (0.82) | KDRFGFR1FLT1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140032198-A1 | APPLICATION OF MULTIDIMENSIONAL MATRIX FOR DRUG MOLECULAS DESIGN AND THE METHODOLOGIES FOR DRUG MOLECULAR DESIGN | YAN JINGBO (CN) | 2014-01-30 | — | — | US | disclosed |
| US-20140032198-A1 | APPLICATION OF MULTIDIMENSIONAL MATRIX FOR DRUG MOLECULAS DESIGN AND THE METHODOLOGIES FOR DRUG MOLECULAR DESIGN | YAN JINGBO (CN) | 2014-01-30 | — | — | US | disclosed |