Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zd-4190 Free Base. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 18/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 15/20 | 1.00 |
| ▸ | FLT1 | P17948 | 15/20 | 1.00 |
| ▸ | FLT4 | P35916 | 12/20 | 1.00 |
| ▸ | EGFR | P00533 | 12/20 | 1.00 |
| ▸ | FGFR2 | P21802 | 5/20 | 1.00 |
| ▸ | FGFR4 | P22455 | 5/20 | 1.00 |
| ▸ | FGFR3 | P22607 | 5/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 3/20 | 1.00 |
| ▸ | RET | P07949 | 2/20 | 0.70 |
| ▸ | KIF5B | P33176 | 2/20 | 0.70 |
| ▸ | TEK | Q02763 | 2/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.63 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.63 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | CIT | O14578 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zd-4190 Free Base SCHEMBL173259 | 1.00 | KDR (1.00) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL14040728 | 1.00 | KDR (1.00) | KDRFGFR1FLT1FLT4EGFR | |
| Zd-4190 Free Base SCHEMBL29363192 | 0.99 | KDR (0.98) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL15445258 | 0.89 | KDR (0.80) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL5177296 | 0.89 | KDR (0.79) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL17520360 | 0.85 | KDR (0.83) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL7459925 | 0.85 | KDR (0.82) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL23117893 | 0.84 | KDR (0.73) | KDRFGFR1FLT1FLT4EGFR | |
| Hydrochloric Acid SCHEMBL7455417 | 0.84 | KDR (0.81) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL7864780 | 0.84 | KDR (0.83) | KDRFGFR1FLT1FLT4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709405-A2 | FLUORESCEIN-LABELED NERVE TARGETING PEPTIDE FORMULATIONS AND RELATED METHODS | Alume Biosciences, Inc. (US) | 2026-03-18 | — | — | EP | disclosed |
| US-20250022536-A1 | IMMUNE REPERTOIRE PATTERNS | IOGENETICS, LLC | 2025-01-16 | — | — | US | disclosed |
| EP-4484952-A2 | OPTIMIZED PEPTIDES FOR TARGETING HUMAN NERVES AND THEIR USE IN IMAGE GUIDED SURGERY, DIAGNOSTICS AND THERAPEUTIC DELIVERY | The Regents of the University of California (US) | 2025-01-01 | — | — | EP | disclosed |
| WO-2024233683-A2 | FLUORESCEIN-LABELED NERVE TARGETING PEPTIDE FORMULATIONS AND RELATED METHODS | ALUME BIOSCIENCES, INC. (US) | 2024-11-14 | — | — | WO | disclosed |
| EP-3661539-B1 | OPTIMIZED PEPTIDES FOR TARGETING HUMAN NERVES AND THEIR USE IN IMAGE GUIDED SURGERY, DIAGNOSTICS AND THERAPEUTIC DELIVERY | UNIV CALIFORNIA (US) | 2024-10-09 | — | — | EP | disclosed |
| CN-111246873-B | Optimized peptides for targeting human nerves and their use in image guided surgery, diagnosis and therapy delivery | 加利福尼亚大学董事会 | 2024-03-01 | — | — | CN | disclosed |
| WO-2022120177-A1 | NERVE TARGETING PEPTIDES AND METHODS OF USE | ALUME BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |