Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zd-4190 Free Base. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 18/20 | 0.98 |
| ▸ | FGFR1 | P11362 | 15/20 | 0.98 |
| ▸ | FLT1 | P17948 | 15/20 | 0.98 |
| ▸ | FLT4 | P35916 | 12/20 | 0.98 |
| ▸ | EGFR | P00533 | 12/20 | 0.98 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.98 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.98 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.98 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.98 |
| ▸ | RET | P07949 | 2/20 | 0.69 |
| ▸ | KIF5B | P33176 | 2/20 | 0.69 |
| ▸ | TEK | Q02763 | 2/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.62 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zd-4190 Free Base SCHEMBL173259 | 0.99 | KDR (1.00) | KDRFGFR1FLT1FLT4EGFR | |
| Zd-4190 Free Base SCHEMBL29729304 | 0.99 | KDR (1.00) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL14040728 | 0.99 | KDR (1.00) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL15445258 | 0.88 | KDR (0.80) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL5177296 | 0.88 | KDR (0.79) | KDRFGFR1FLT1FLT4EGFR | |
| Hydrochloric Acid SCHEMBL7455417 | 0.85 | KDR (0.81) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL17520360 | 0.84 | KDR (0.83) | KDRFGFR1FLT1FLT4EGFR | |
| Hydrochloric Acid SCHEMBL7866007 | 0.84 | KDR (0.82) | KDRFGFR1FLT1FLT4EGFR | |
| SCHEMBL7459925 | 0.84 | KDR (0.82) | KDRFGFR1FLT1FLT4EGFR | |
| Hydrochloric Acid SCHEMBL7864775 | 0.84 | KDR (0.98) | KDRFGFR1FLT1FLT4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250170090-A1 | METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT | ONQUALITY PHARMACEUTICALS CHINA LTD (CN) | 2025-05-29 | — | — | US | disclosed |
| EP-4470565-A1 | METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT | OnQuality Pharmaceuticals China Ltd. (CN) | 2024-12-04 | — | — | EP | disclosed |
| CN-116211789-A | Composition and use thereof | 上海岸阔医药科技有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-114028568-A | Method for preventing or treating side effects of tumor therapy | 上海岸阔医药科技有限公司 | 2022-02-11 | — | — | CN | disclosed |
| CN-113975264-A | Method for preventing or treating side effects of tumor therapy | 上海岸阔医药科技有限公司 | 2022-01-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250170090-A1 | METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT | VHL, SLC10A1, NNMT | KDR 4883/4885FGFR1 4524/4885FLT1 4838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.