Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 15/20 | 0.79 |
| ▸ | FLT1 | P17948 | 15/20 | 0.79 |
| ▸ | EGFR | P00533 | 12/20 | 0.79 |
| ▸ | FLT4 | P35916 | 11/20 | 0.79 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.79 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.79 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.79 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | KIF5B | P33176 | 2/20 | 0.52 |
| ▸ | GAK | O14976 | 2/20 | 0.49 |
| ▸ | TEK | Q02763 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zd-4190 Free Base SCHEMBL29729304 | 0.89 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL14040728 | 0.89 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| Zd-4190 Free Base SCHEMBL173259 | 0.89 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| Zd-4190 Free Base SCHEMBL29363192 | 0.88 | KDR (0.98) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL1894407 | 0.83 | EGFR (0.70) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL16682500 | 0.78 | EGFR (0.78) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL15445258 | 0.77 | KDR (0.80) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL6477890 | 0.77 | KDR (0.58) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL6431753 | 0.74 | FLT1 (0.78) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL6097222 | 0.74 | KDR (0.79) | KDRFGFR1FLT1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272186-B1 | THERAPEUTIC COMBINATIONS OF ANTIHYPERTENSIVE AND ANTIANGIOGENIC AGENTS | ASTRAZENECA AB (SE) | 2007-02-28 | — | — | EP | claimed |