Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | ASGR1 | P07306 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL131486 | 1.00 | HSD11B1 (0.43) | HSD11B1PIK3R1PIK3CACHRM2CHRM1 | |
| SCHEMBL154601 | 1.00 | HSD11B1 (0.43) | HSD11B1PIK3R1PIK3CACHRM2CHRM1 | |
| SCHEMBL132146 | 0.87 | HSD11B1 (0.42) | HSD11B1CHRM2CHRM1CHRM3KAT6A | |
| SCHEMBL22694964 | 0.80 | HSD11B1 (0.44) | HSD11B1PIK3R1PIK3CACHRM2CHRM1 | |
| SCHEMBL8912028 | 0.80 | HSD11B1 (0.50) | HSD11B1CHRM1CHRM3KDM4DSPR | |
| SCHEMBL12731249 | 0.79 | HSD11B1 (0.43) | HSD11B1PIK3R1PIK3CACHRM2CHRM1 | |
| SCHEMBL15685555 | 0.79 | HSD11B1 (0.43) | HSD11B1PIK3R1PIK3CACHRM2CHRM1 | |
| SCHEMBL12731246 | 0.79 | HSD11B1 (0.43) | HSD11B1PIK3R1PIK3CACHRM2CHRM1 | |
| SCHEMBL12731687 | 0.79 | HSD11B1 (0.43) | HSD11B1PIK3R1PIK3CACHRM2CHRM1 | |
| SCHEMBL24700252 | 0.77 | HSD11B1 (0.44) | HSD11B1PIK3R1PIK3CACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611810-A1 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE DERIVATIVES | Grünenthal GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| US-20120058999-A1 | Substituted Tetrahydropyrrolopyrazine Compounds | GRUENENTHAL GMBH (DE) | 2012-03-08 | — | — | US | disclosed |
| WO-2012028331-A1 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE DERIVATIVES | Grünenthal GmbH (DE) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058999-A1 | Substituted Tetrahydropyrrolopyrazine Compounds | BDKRB1, BDKRB2, LTB4R | HSD11B1 2315/4885PIK3R1 3013/4885PIK3CA 1244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.