Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 11/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740305 | 0.80 | GPR17 (1.00) | GPR17KDM4EPOLBMAPTFBP1 | |
| SCHEMBL15463467 | 0.76 | GPR17 (0.66) | GPR17EGFRFBP1FFAR1 | |
| SCHEMBL15463521 | 0.76 | GPR17 (0.66) | GPR17KDM4EFBP1ALDH1A1HPGD | |
| SCHEMBL15463511 | 0.76 | GPR17 (0.66) | GPR17FBP1HPGD | |
| SCHEMBL15463476 | 0.76 | GPR17 (0.66) | GPR17FBP1 | |
| SCHEMBL15463559 | 0.73 | GPR17 (0.69) | GPR17KDM4EEGFRFBP1FFAR1 | |
| SCHEMBL15463544 | 0.72 | GPR17 (0.46) | GPR17FBP1 | |
| SCHEMBL14988768 | 0.71 | NPSR1 (0.57) | GPR17KDM4EPOLBMAPTEGFR | |
| SCHEMBL29255722 | 0.70 | KDM4E (1.00) | GPR17KDM4EPOLBMAPTALDH1A1 | |
| SCHEMBL15463507 | 0.68 | GPR17 (0.66) | GPR17EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2567698-B1 | GPR 17 agonists and screening assay | UNIV BONN (DE) | 2014-02-12 | — | — | EP | claimed |