Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ibafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | TOP2A | P11388 | 8/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibafloxacin SCHEMBL10073765 | 1.00 | LMNA (0.69) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| Ibafloxacin SCHEMBL154637 | 1.00 | LMNA (0.69) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL8083425 | 0.89 | LMNA (0.70) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL10841687 | 0.88 | LMNA (0.69) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL16518639 | 0.88 | KDM4E (0.61) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL10784346 | 0.87 | LMNA (0.68) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL10785119 | 0.87 | LMNA (0.68) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| Water SCHEMBL10842574 | 0.87 | LMNA (0.68) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| SCHEMBL10782548 | 0.87 | LMNA (0.68) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A | |
| Water SCHEMBL10788704 | 0.86 | LMNA (0.67) | LMNAKDM4ESMN1; SMN2CYP1A2TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119838022-A | Amatoxin conjugates containing branched linkers | 杭州多禧生物科技有限公司 | 2025-04-18 | — | — | CN | claimed |
| CN-119588317-A | Magnetic covalent framework material and application thereof in detection of bee product quinolone medicines | 武汉儿童医院 | 2025-03-11 | — | — | CN | claimed |
| CN-113423430-B | Amatoxin conjugates containing branched linkers | 杭州多禧生物科技有限公司 | 2024-12-03 | — | — | CN | claimed |
| CN-118878838-A | Preparation method and application of metal organic framework material for adsorbing quinolone medicines | 新疆畜牧科学院畜牧业质量标准研究所（新疆维吾尔自治区种羊与羊毛羊绒质量安全监督检验中心） | 2024-11-01 | — | — | CN | claimed |
| CN-114965777-B | Ultra-high performance liquid chromatography tandem mass spectrometry detection method for quinolone antibiotics in sediment | 浙江省海洋水产研究所 | 2024-09-06 | — | — | CN | claimed |
| CN-118557747-A | Conjugates of cell binding molecules and camptothecin analogs | 杭州多禧生物科技有限公司 | 2024-08-30 | — | — | CN | claimed |
| CN-118340907-A | Polymer conjugates comprising bioactive agents | 波利艾克蒂瓦有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-117805289-A | Method for simultaneously detecting 72 antibiotics in human urine | 中国疾病预防控制中心环境与健康相关产品安全所 | 2024-04-02 | — | — | CN | claimed |
| CN-115558123-B | Imprinting type iron-based metal organic framework material and preparation method and application thereof | 华中农业大学 | 2023-12-22 | — | — | CN | claimed |
| CN-116773689-A | Method for rapidly screening various antibacterial drug residues in livestock manure and application thereof | 中国动物卫生与流行病学中心 | 2023-09-19 | — | — | CN | claimed |
| CN-114594185-B | Detection method and application of quinolone drug residues in aquatic products based on LDHs | 连云港海关综合技术中心 | 2023-07-04 | — | — | CN | claimed |
| CN-113945648-B | Method for detecting residual veterinary drugs in dairy products | 内蒙古蒙牛乳业（集团）股份有限公司 | 2023-06-16 | — | — | CN | claimed |
| WO-2026102307-A1 | ACELLULAR BLOOD ALTERNATIVE FOR TRANSFUSION AND ORGAN PERFUSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-05-15 | — | — | WO | disclosed |
| US-20250352663-A1 | Nanoclusters Functionalized with Adenosine Triphosphate or an Analogue and Their Use | UNIV LELAND STANFORD JUNIOR (US) | 2025-11-20 | — | — | US | disclosed |
| US-20250177558-A1 | Functionalized Nanoclusters and Their Use in Treating Bacterial Infections | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2025-06-05 | — | — | US | disclosed |
| CN-120076831-A | Anti-ROR 1 antibodies and antibody conjugates, compositions comprising anti-ROR 1 antibodies or antibody conjugates, and methods of making and using anti-ROR 1 antibodies and antibody conjugates | 苏特罗生物制药公司 | 2025-05-30 | — | — | CN | disclosed |
| EP-4110330-A1 | ANTI-VIRAL COMPOUNDS AND METHODS FOR ADMINISTRATION THEREOF | Gregg, John Malcolm Hall (US) | 2023-01-04 | — | — | EP | disclosed |
| US-20220339293-A1 | FUNCTIONALIZED NANOPARTICLES AND THEIR USE IN TREATING BACTERIAL INFECTIONS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-10-27 | — | — | US | disclosed |
| EP-3996751-A1 | FUNCTIONALIZED NANOPARTICLES AND THEIR USE IN TREATING BACTERIAL INFECTIONS | The Board Of Trustees Of The Leland Stanford Junior University (US) | 2022-05-18 | — | — | EP | disclosed |
| CN-112321613-B | Preparation method of idoxaban tosylate and isomer thereof | 江苏华阳制药有限公司 | 2022-04-12 | — | — | CN | disclosed |