Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.68 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10286238 | 1.00 | MTNR1A (0.68) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL11896371 | 0.84 | MTNR1A (0.77) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL16039087 | 0.83 | MTNR1A (0.51) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL14241869 | 0.82 | MTNR1A (0.72) | MTNR1AMTNR1BHPGDCNR1TAAR1 | |
| SCHEMBL1010724 | 0.81 | MTNR1A (1.00) | MTNR1AMTNR1BHPGDCNR1TAAR1 | |
| SCHEMBL8419482 | 0.81 | MTNR1A (0.67) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL807757 | 0.81 | HIF1A (0.54) | KMT2AALDH1A1SMN1; SMN2HPGDGLA | |
| SCHEMBL11306449 | 0.81 | HDAC3 (0.52) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL10289223 | 0.81 | MTNR1A (0.70) | MTNR1AMTNR1BKMT2AMEN1ALDH1A1 | |
| SCHEMBL15468130 | 0.81 | HIF1A (0.54) | KMT2AALDH1A1SMN1; SMN2HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946260-B2 | 17α-hydroxylase/C17,20-lyase inhibitors | NOVARTIS AG (CH) | 2015-02-03 | — | — | US | disclosed |
| US-20140045872-A1 | 17a-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2014-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045872-A1 | 17a-HYDROXYLASE/C17,20-LYASE INHIBITORS | CYP17A1, CYP21A2, HSD17B1 | MTNR1A 910/4885MTNR1B 1131/4885KMT2A 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.