Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CCL2 | P13500 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10079284 | 0.83 | OPRM1 (0.42) | HTR2AHTR2CHTR2BPRCPOPRM1 | |
| SCHEMBL14170111 | 0.78 | BRD4 (0.38) | HTR2AHTR2CHTR2BPRCPNOTUM | |
| SCHEMBL15468300 | 0.74 | OPRM1 (0.43) | OPRM1 | |
| SCHEMBL15468334 | 0.74 | PRCP (0.38) | HTR2AHTR2CHTR2BPRCPNOTUM | |
| SCHEMBL10060256 | 0.74 | PRCP (0.38) | HTR2AHTR2CHTR2BPRCPNOTUM | |
| SCHEMBL14392106 | 0.74 | PRCP (0.38) | HTR2AHTR2CHTR2BPRCPNOTUM | |
| SCHEMBL14170247 | 0.72 | XIAP (0.38) | HTR2AHTR2CHTR2BPRCPOPRM1 | |
| SCHEMBL29165282 | 0.72 | NOTUM (0.44) | HTR2AHTR2CHTR2BPRCPNOTUM | |
| SCHEMBL31019452 | 0.72 | NOTUM (0.44) | HTR2AHTR2CHTR2BPRCPNOTUM | |
| SCHEMBL14169897 | 0.71 | OPRM1 (0.40) | PRCPOPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648094-B2 | IAP BIR domain binding compounds | PHARMASCIENCE, INC. (CA) | 2014-02-11 | — | — | US | disclosed |