Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15468037 | 0.86 | KIF11 (0.45) | NPC1RAB9ASMN1; SMN2MAPTTRPM8 | |
| SCHEMBL15467342 | 0.85 | TRPM8 (0.53) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL15467345 | 0.85 | TRPM8 (0.53) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL16418790 | 0.81 | TRPM8 (0.35) | NPC1RAB9ASMN1; SMN2LMNATRPM8 | |
| SCHEMBL15469407 | 0.78 | TRPM8 (0.52) | NPC1RAB9ASMN1; SMN2POLBPTGS2 | |
| SCHEMBL15467040 | 0.77 | TRPM8 (0.54) | NPC1RAB9ASMN1; SMN2LMNATRPM8 | |
| SCHEMBL15469370 | 0.76 | TRPM8 (0.55) | NPC1RAB9APOLBTRPM8KMT2A | |
| SCHEMBL15469410 | 0.76 | TRPM8 (0.51) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL9819031 | 0.76 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL15467015 | 0.75 | TRPM8 (0.52) | NPC1RAB9ASMN1; SMN2POLBTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952009-B2 | Chroman derivatives as TRPM8 inhibitors | AMGEN INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-20150031668-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC (US) | 2015-01-29 | — | — | US | disclosed |
| US-20140045855-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC. (US) | 2014-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031668-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | TRPM8, TRPM5, TRPM7 | NPC1 702/4885RAB9A 1056/4885SMN1; SMN2 923/4885 |
| US-20140045855-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | TRPM8, TRPM5, TRPM7 | NPC1 702/4885RAB9A 1056/4885SMN1; SMN2 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.