Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.62 |
| ▸ | HTRA2 | O43464 | 8/20 | 0.59 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.59 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.55 |
| ▸ | ALB | P02768 | 2/20 | 0.52 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15470452 | 0.98 | WDR5 (0.60) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL21766805 | 0.86 | WDR5 (0.63) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL21766803 | 0.85 | WDR5 (0.61) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL16882196 | 0.82 | WDR5 (0.55) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL21766754 | 0.82 | HTRA2 (0.60) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL21766490 | 0.81 | WDR5 (0.58) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL14932664 | 0.81 | HTRA2 (0.58) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL20230290 | 0.81 | WDR5 (0.63) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL12903760 | 0.81 | WDR5 (0.55) | WDR5HTRA2HTRA1FOLH1ALB | |
| SCHEMBL1687874 | 0.80 | HTRA2 (0.55) | WDR5HTRA2HTRA1FOLH1ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221215-B2 | Hydrogen bond surrogate macrocycles as modulators of Ras | NEW YORK UNIVERSITY (US) | 2019-03-05 | — | — | US | disclosed |
| US-20150239935-A1 | HYDROGEN BOND SURROGATE MACROCYCLES AS MODULATORS OF RAS | NEW YORK UNIVERSITY (US) | 2015-08-27 | — | — | US | disclosed |
| US-8987412-B2 | Hydrogen bond surrogate macrocycles as modulators of Ras | NEW YORK UNIVERSITY (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140045769-A1 | HYDROGEN BOND SURROGATE MACROCYCLES AS MODULATORS OF RAS | NEW YORK UNIVERSITY (US) | 2014-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239935-A1 | HYDROGEN BOND SURROGATE MACROCYCLES AS MODULATORS OF RAS | KRAS, HRAS, NRAS | WDR5 4162/4885HTRA2 2887/4885HTRA1 2348/4885 |
| US-10221215-B2 | Hydrogen bond surrogate macrocycles as modulators of Ras | KRAS, HRAS, NRAS | WDR5 4162/4885HTRA2 2887/4885HTRA1 2348/4885 |
| US-20140045769-A1 | HYDROGEN BOND SURROGATE MACROCYCLES AS MODULATORS OF RAS | KRAS, HRAS, NRAS | WDR5 4162/4885HTRA2 2887/4885HTRA1 2348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.