Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480433

SCHEMBL15480433

SCHEMBL15480433

O=C(CCCCCCC(=O)Nc1c(F)ccc(F)c1F)Nc1c(F)ccc(F)c1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 14/20 0.47
▸ HDAC3 O15379 13/20 0.47
▸ HDAC2 Q92769 13/20 0.47
▸ HDAC6 Q9UBN7 13/20 0.47
▸ HDAC4 P56524 10/20 0.46
▸ HDAC7 Q8WUI4 10/20 0.46
▸ HDAC11 Q96DB2 10/20 0.46
▸ HDAC8 Q9BY41 10/20 0.46
▸ HDAC9 Q9UKV0 10/20 0.46
▸ HDAC5 Q9UQL6 10/20 0.46
▸ HDAC10 Q969S8 10/20 0.46
▸ NCOR2 Q9Y618 4/20 0.46
▸ MEN1 O00255 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ TSHR P16473 1/20 0.44
▸ NCOR1 O75376 2/20 0.42
▸ EGFR P00533 2/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ BRD4 O60885 1/20 0.42
▸ NR1I2 O75469 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15480420 0.93 HDAC1 (0.58) HDAC1HDAC3HDAC2HDAC6HDAC4
SCHEMBL15480432 0.83 HDAC1 (0.53) HDAC1HDAC3HDAC2HDAC6HDAC4
SCHEMBL15480437 0.78 MEN1 (0.67) HDAC1HDAC3HDAC2HDAC6HDAC4
SCHEMBL15480436 0.76 HDAC3 (0.49) HDAC1HDAC3HDAC2HDAC6HDAC4
SCHEMBL22404608 0.74 HDAC3 (0.40) HDAC1HDAC3HDAC2HDAC6HDAC4
SCHEMBL20560600 0.72 CES2 (0.40) MEN1KMT2AGAA
SCHEMBL15480423 0.72 MEN1 (0.59) HDAC1HDAC3HDAC2HDAC6HDAC4
SCHEMBL31032253 0.72 EP300 (0.52) HDAC1HDAC3HDAC2HDAC6HDAC4
SCHEMBL29272418 0.72 EP300 (0.52) HDAC1HDAC3HDAC2HDAC6HDAC4
SCHEMBL28291532 0.71 EPHX2 (0.63) MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC3 1/4885HDAC2 3/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC3 1/4885HDAC2 3/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC3 1/4885HDAC2 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.