Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480586

SCHEMBL15480586

SCHEMBL15480586

Cc1nc2cc(S(=O)(=O)Nc3ccc(C(=O)NO)cc3)ccc2s1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.60
▸ LMNA P02545 8/20 0.54
▸ HTT P42858 7/20 0.54
▸ ALOX15 P16050 1/20 0.54
▸ MAPK1 P28482 1/20 0.54
▸ SMN1; SMN2 Q16637 7/20 0.54
▸ PKM P14618 2/20 0.54
▸ NOD2 Q9HC29 1/20 0.54
▸ HDAC8 Q9BY41 3/20 0.53
▸ HDAC6 Q9UBN7 3/20 0.53
▸ HDAC3 O15379 2/20 0.53
▸ HDAC11 Q96DB2 2/20 0.53
▸ TRPV1 Q8NER1 2/20 0.53
▸ TP53 P04637 1/20 0.52
▸ NPSR1 Q6W5P4 1/20 0.52
▸ NPC1 O15118 2/20 0.50
▸ RAB9A P51151 2/20 0.50
▸ POLB P06746 2/20 0.49
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ BRPF1 P55201 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15480583 0.86 HDAC6 (0.50) ALDH1A1LMNAHTTSMN1; SMN2HDAC8
SCHEMBL15480582 0.86 HDAC6 (0.50) ALDH1A1LMNAHTTALOX15MAPK1
SCHEMBL15480564 0.86 MAPT (0.51) ALDH1A1LMNAHTTALOX15SMN1; SMN2
SCHEMBL4940110 0.84 LMNA (0.60) ALDH1A1LMNAHTTALOX15MAPK1
SCHEMBL15482249 0.83 HDAC6 (0.47) ALDH1A1LMNAHTTHDAC8HDAC6
SCHEMBL4937462 0.82 TRPV1 (0.59) ALDH1A1LMNAHTTALOX15MAPK1
SCHEMBL23054872 0.81 TRPV1 (0.47) ALDH1A1HDAC8HDAC6HDAC3HDAC11
SCHEMBL24124970 0.81 GPR27 (0.62) ALDH1A1LMNAHTTSMN1; SMN2PKM
SCHEMBL15480643 0.80 ALDH1A1 (0.61) ALDH1A1LMNAHTTMAPK1SMN1; SMN2
SCHEMBL19058585 0.80 NPC1 (0.71) ALDH1A1SMN1; SMN2HDAC8HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 ALDH1A1 3068/4885LMNA 489/4885HTT 546/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 ALDH1A1 3068/4885LMNA 489/4885HTT 546/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.