Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 8/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 3/20 | 0.47 |
| ▸ | NOS1 | P29475 | 3/20 | 0.47 |
| ▸ | NOS2 | P35228 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37182814 | 0.76 | SLC7A5 (0.73) | SLC7A5TDP1NOS3NOS1NOS2 | |
| SCHEMBL455836 | 0.76 | SLC7A5 (0.73) | SLC7A5TDP1NOS3NOS1NOS2 | |
| SCHEMBL26008172 | 0.76 | SLC7A5 (0.73) | SLC7A5TDP1NOS3NOS1NOS2 | |
| SCHEMBL455835 | 0.76 | SLC7A5 (0.73) | SLC7A5TDP1NOS3NOS1NOS2 | |
| SCHEMBL1549947 | 0.76 | LMNA (0.47) | SLC7A5TDP1LMNANOS3NOS1 | |
| Hydrochloric Acid SCHEMBL598769 | 0.75 | SLC7A5 (0.71) | SLC7A5TDP1NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL30655752 | 0.75 | SLC7A5 (0.71) | SLC7A5TDP1NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL598770 | 0.75 | SLC7A5 (0.71) | SLC7A5TDP1NOS3NOS1NOS2 | |
| SCHEMBL321517 | 0.74 | SLC7A5 (0.70) | SLC7A5NOS3NOS1NOS2PTGS1 | |
| SCHEMBL1061213 | 0.74 | SLC7A5 (0.70) | SLC7A5NOS3NOS1NOS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2011-04-27 | — | — | EP | disclosed |