Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NOS3 | P29474 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | NOS2 | P35228 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749002 | 0.77 | LMNA (0.46) | LMNATDP1CNR2MEN1KMT2A | |
| SCHEMBL4551989 | 0.76 | NOS3 (0.60) | LMNATDP1NOS3NOS1NOS2 | |
| SCHEMBL4792772 | 0.76 | NOS3 (0.60) | LMNATDP1NOS3NOS1NOS2 | |
| SCHEMBL1549942 | 0.76 | SLC7A5 (0.55) | LMNATDP1NOS3NOS1NOS2 | |
| SCHEMBL1502390 | 0.74 | ABL1 (0.38) | LMNATDP1CNR2TSHRPOLB | |
| SCHEMBL1527682 | 0.73 | PKM (0.58) | LMNATDP1NOS3NOS1NOS2 | |
| SCHEMBL31370153 | 0.73 | PKM (0.58) | LMNATDP1NOS3NOS1NOS2 | |
| SCHEMBL1527683 | 0.73 | PKM (0.58) | LMNATDP1NOS3NOS1NOS2 | |
| SCHEMBL29475631 | 0.73 | PKM (0.58) | LMNATDP1NOS3NOS1NOS2 | |
| SCHEMBL30440587 | 0.72 | NOS3 (0.59) | LMNATDP1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2011-04-27 | — | — | EP | disclosed |