Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15499643 | 0.96 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL6962792 | 0.82 | KCNK3 (0.54) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL15498192 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL4627398 | 0.81 | KMT2A (0.44) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL15499582 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL15499583 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL18994857 | 0.78 | CHRNB4 (0.55) | — | |
| SCHEMBL9036988 | 0.78 | MEN1 (0.50) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL15499631 | 0.78 | NPC1 (0.50) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL15499632 | 0.77 | MAPT (0.48) | SMN1; SMN2RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682950-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-06-20 | — | — | US | disclosed |
| US-9682950-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-06-02 | — | — | US | disclosed |
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-06-02 | — | — | US | disclosed |
| US-9242957-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2016-01-26 | — | — | US | disclosed |
| US-9242957-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2016-01-26 | — | — | US | disclosed |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-09-11 | — | — | US | disclosed |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-09-11 | — | — | US | disclosed |
| US-8735606-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-8735606-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | SMN1; SMN2 89/4885RAB9A 3208/4885NPC1 816/4885 |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | SMN1; SMN2 89/4885RAB9A 3384/4885NPC1 878/4885 |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | SMN1; SMN2 89/4885RAB9A 3384/4885NPC1 878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.