Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 5/20 | 0.32 |
| ▸ | BCHE | P06276 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15510105 | 0.91 | TACR1 (0.34) | HSD11B1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL2529406 | 0.88 | TP53 (0.37) | HSD11B1KMT2APTGS2POLB | |
| SCHEMBL2538485 | 0.85 | AR (0.38) | ALDH1A1MAPTKMT2ALMNATSHR | |
| SCHEMBL2532333 | 0.79 | TP53 (0.41) | HSD11B1ALDH1A1KMT2APOLB | |
| SCHEMBL15509513 | 0.78 | ACHE (0.38) | ALDH1A1KMT2AACHEBCHEPOLB | |
| SCHEMBL15509667 | 0.78 | ACHE (0.36) | ALDH1A1KMT2AACHEBCHE | |
| SCHEMBL15510199 | 0.77 | FAAH (0.41) | ACHEBCHE | |
| SCHEMBL15509602 | 0.77 | ADRB1 (0.39) | ACHEBCHE | |
| SCHEMBL14331239 | 0.77 | TP53 (0.34) | HSD11B1ALDH1A1LMNA | |
| SCHEMBL2532496 | 0.76 | SMN1; SMN2 (0.38) | ALDH1A1MAPTKMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558449-B1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-03-05 | — | — | EP | claimed |