Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.52 |
| ▸ | MEN1 | O00255 | 13/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 7/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1551031 | 1.00 | MAPT (0.52) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10463955 | 0.82 | MEN1 (0.48) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10463956 | 0.82 | MEN1 (0.48) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL393792 | 0.82 | GAA (0.44) | MAPTALDH1A1SMN1; SMN2GAAPOLB | |
| SCHEMBL18793175 | 0.82 | GAA (0.44) | MAPTALDH1A1SMN1; SMN2GAAPOLB | |
| SCHEMBL393793 | 0.82 | GAA (0.44) | MAPTALDH1A1SMN1; SMN2GAAPOLB | |
| SCHEMBL1550324 | 0.80 | SMN1; SMN2 (0.43) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1550322 | 0.80 | SMN1; SMN2 (0.43) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4333571 | 0.77 | SMN1; SMN2 (0.45) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4333564 | 0.77 | SMN1; SMN2 (0.45) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131074-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-05-23 | — | — | US | disclosed |
| US-8372837-B2 | Pyridone and pyridazone analogues as GPR119 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | disclosed |
| US-20110263548-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| CN-102159566-A | Pyridone and pyridazone analogues as gpr119 modulators | BRISTOL MYERS SQUIBB CO | 2011-08-17 | — | — | CN | disclosed |
| EP-2313395-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010009183-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131074-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | GPR119, GPR4, GPR3 | MAPT 3761/4885KMT2A 3211/4885MEN1 2531/4885 |
| US-20110263548-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | GPR119, GPR4, GPR3 | MAPT 3848/4885KMT2A 3266/4885MEN1 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.