⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053972 | 0.68 | — | — | |
| SCHEMBL4515850 | 0.62 | ADRB1 (0.44) | — | |
| SCHEMBL8410646 | 0.61 | LMNA (0.41) | — | |
| SCHEMBL15421672 | 0.60 | MEN1 (0.30) | — | |
| SCHEMBL293612 | 0.59 | KDM4E (0.34) | — | |
| SCHEMBL15009410 | 0.55 | CA1 (0.31) | — | |
| SCHEMBL8495575 | 0.55 | — | — | |
| SCHEMBL13661859 | 0.53 | KDM4E (0.36) | — | |
| SCHEMBL17103386 | 0.50 | — | — | |
| SCHEMBL3075460 | 0.49 | KDM4E (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499467-B2 | Ortho-fluoro substituted compounds for the treatment of metabolic diseases | CALDAN THERAPEUTICS LIMITED (GB) | 2016-11-22 | — | — | US | claimed |
| US-20140058125-A1 | ORTHO-FLUORO SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES | SYDDANSK UNIVERSITET (DK) | 2014-02-27 | — | — | US | claimed |
| EP-2694465-A1 | ORTHO-FLUORO SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES | Syddansk Universitet (DK) | 2014-02-12 | — | — | EP | claimed |
| US-8586607-B2 | Compounds for the treatment of metabolic diseases | SYDDANSK UNIVERSITET (DK) | 2013-11-19 | — | — | US | claimed |
| WO-2012136221-A1 | ORTHO-FLUORO SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES | SYDDANSK UNIVERSITET (DK) | 2012-10-11 | — | — | WO | claimed |
| EP-2313360-B1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES | UNIV SYDDANSK (DK) | 2012-09-05 | — | — | EP | claimed |
| US-20110152315-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES | SYDDANSK UNIVERSITET | 2011-06-23 | — | — | US | claimed |
| EP-2313360-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES | Syddansk Universitet (DK) | 2011-04-27 | — | — | EP | claimed |
| WO-2010012650-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES | SYDDANSK UNIVERSITET (DK) | 2010-02-04 | — | — | WO | claimed |
| US-10836688-B2 | Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose | ABBVIE INC. (US) | 2020-11-17 | — | — | US | disclosed |
| US-20200148610-A1 | ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE | ABBVIE INC. | 2020-05-14 | — | — | US | disclosed |
| EP-2962687-B1 | TAU AGGREGATION INHIBITOR | THE DOSHISHA (JP) | 2019-06-05 | — | — | EP | disclosed |
| US-9907799-B2 | Tau aggregation inhibitor | THE DOSHISHA (JP) | 2018-03-06 | — | — | US | disclosed |
| US-9809604-B2 | DGAT1 inhibitor and preparation method and use thereof | QINGDAO HUANGHAI PHARMACEUTICAL CO., LTD. (CN) | 2017-11-07 | — | — | US | disclosed |
| WO-2008075196-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| EP-1549646-A4 | PIPERIDINE DERIVATIVES | AMGEN INC (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20060229311-A1 | Isatine derivatives with neurotrophic activity | GROENBORG METTE | 2006-10-12 | — | — | US | disclosed |
| EP-1549646-A2 | PIPERIDINE DERIVATIVES | Tularik Inc. (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004028459-A2 | PIPERIDINE DERIVATIVES | TULARIK INC. (US) | 2004-04-08 | — | — | WO | disclosed |
| US-4950662-A | ANTIBIOTIC | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-21 | — | — | US | disclosed |