Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053972 | 0.85 | — | — | |
| SCHEMBL1385232 | 0.81 | CHKA (0.32) | ALDH1A1MAPTMEN1HTTKMT2A | |
| SCHEMBL4515850 | 0.78 | ADRB1 (0.44) | ALDH1A1KDM4E | |
| SCHEMBL28416073 | 0.65 | ALDH1A1 (0.42) | LMNAALDH1A1MAPTMEN1HTT | |
| SCHEMBL4510267 | 0.65 | LMNA (0.42) | LMNAALDH1A1MAPTMEN1HTT | |
| SCHEMBL9093746 | 0.65 | LMNA (0.71) | LMNAALDH1A1MAPTMEN1HTT | |
| SCHEMBL1256702 | 0.64 | POLB (0.37) | LMNAMEN1HTTKMT2ATP53 | |
| SCHEMBL1607692 | 0.64 | LMNA (0.41) | LMNAALDH1A1MAPTMEN1HTT | |
| SCHEMBL189494 | 0.64 | LMNA (0.50) | LMNAALDH1A1MAPTMEN1HTT | |
| SCHEMBL4723299 | 0.63 | LMNA (0.44) | LMNAMAPTHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985894-A | USEFUL IN THE TREATMENT OF CARDIOVASCULAR ILLNESSES | HOECHST MARION ROUSSEL (FR) | 1999-11-16 | — | — | US | disclosed |